Human Biology
نویسندگان
چکیده
منابع مشابه
Role of Epigenetics in Biology and Human Diseases
For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurod...
متن کاملHuman Cancer Biology
Purpose: Abnormal accumulation and dysregulation of the epidermal growth factor receptor family member HER3 is associated with the development of various human cancers including those of the breast, lung, and ovary. We have previously shown that in melanoma HER3 is frequently overexpressed and is associated with poor prognosis. However, the importance of HER3 in colon cancer and its putative pr...
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Purpose: In addition to genomic signaling, it is accepted that estrogen receptor-a (ERa) has nonnuclear signaling functions, which correlate with tamoxifen resistance in preclinical models. However, evidence for cytoplasmic ER localization inhumanbreast tumors is less established.We sought to determine the presence and implications of nonnuclear ER in clinical specimens. Experimental Design:Apa...
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Purpose:An improved understanding of themolecular pathogenesis of brainmetastases, one of themost common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between brain and extracranialmetastases would support the need for the development of organ-specific t...
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Purpose:Myeloid-derived suppressor cells (MDSC)have emerged as an immune-regulatory cell type that is expanded in tumor-bearingmice, but less is known about their immune-suppressive role in patients with
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ژورنال
عنوان ژورنال: Nature
سال: 1969
ISSN: 0028-0836,1476-4687
DOI: 10.1038/224830b0